U.S. President Donald Trump on Saturday gave Iran 48 hours to reopen the Strait of Hormuz to shipping or face the destruction of its energy infrastructure, as Tehran launched its most destructive attack yet on Israel.

Iran's powerful parliament speaker Mohammad Bagher Ghalibaf threatened on Sunday to irreversibly destroy vital infrastructure across the region if the United States and Israel attacked its own.

Israeli Prime Minister Benjamin Netanyahu vowed on Sunday to pursue senior commanders of Iran's Revolutionary Guards "personally", during a visit to an Israeli town struck by an Iranian missile the previous day.

Iranian missile strikes on two southern Israeli towns wounded more than 100 people on Saturday, medics said, after Israeli air defence systems failed to intercept the projectiles.

Benjamin Netanyahu must soon decide when to hold Israel’s next elections. With war raging on multiple fronts and no end in sight, Israel’s enemies in Iran and Lebanon may help make that decision for him.

After three weeks of war, the Trump administration has begun initial discussions on the next phase and what peace talks with Iran might look like, a U.S. official and a source with knowledge told U.S. news portal Axios.

Trump said Friday that he was considering "winding down" the war, though U.S. officials said the expectation was there would still be two to three additional weeks of fighting. In the meantime, Trump's advisers want to start laying groundwork for diplomacy.

Israeli Defense Minister Israel Katz warned that the United States and Israel would intensify their strikes on Iran in the coming week starting Sunday.

The United States and Israel struck Iran's Natanz nuclear facility on Saturday, the Islamic republic's atomic energy organization said.

U.S. President Donald Trump said Friday that he was considering "winding down" military operations against Iran, as the United States temporarily eased sanctions on Iranian oil shipments to stem a global supply crisis.

Iran launched a new wave of drone and missile attacks on Saudi Arabia and Israel meanwhile after supreme leader Mojtaba Khamenei claimed to have dealt a "dizzying blow" to his country's enemies.

Here are the latest developments in the Middle East war: